Finding new therapies for brain diseases requires preclinical models and assays with increased clinical relevance. a:head aims to develop a human-based platform for generating complex brain-like tissue and analyzing neuronal network activity. Brain organoids are a biomedical revolution representing the most advanced in vitro experimental model of human brain. These 3D cultures mimic the structure and function of the brain with the promise of scalability to enable high-throughput screening of patient neural networks. We are developing a next-generation brain organoid-based drug discovery engine.