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Diakonos Oncology

February 26, 2024
Oncology
Diakonos Oncology
Clinical Efficacy in the Toughest Cancers -- Cracking the Code on Dendritic Cell Therapy and Tumor Infiltrating Lymphocytes Diakonos Oncology is developing two cell therapy technologies developed at MD Anderson and Baylor College of Medicine. The seed-stage company is in a unique position due to early clinical progress achieved under an investigator sponsored protocol for the lead asset, DOC1021. The Phase 1 study in “moonshot” GBM patients is now fully enrolled (n=18) with topline data expected in 1H24. To date, interim median PFS is 9+ mo. (vs 4 mo. expected) and interim average survival for Cohort 1 (low dose, n=3) is 19.8+ mo. (vs 15 mo. expected). Clinical benefits have been observed in multiple (10+) other cancer types in IST and IST-like settings (incl. 4/5 CRs in PDAC patients). Fast Track & Orphan Drug Designation have been awarded for DOC1021 based on 1) observed survival benefit in GBM Phase 1 and 2) no attributable Serious Adverse Events (SAEs) to date.
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