Cytovation
February 26, 2024
Oncology
Cytovation is a clinical-stage oncology biotech focused on the development of CyPep-1, a first-in-class synthetic peptide designed to drive a systemic anti-cancer immune response, with a unique dual mode of action:
(1) Selective targeting of the cancer cell plasma membrane releases neoantigens that drive a tumor-specific immune response,
(2) inhibition of the beta-catenin oncogenic pathway promotes immune activation and reverses immune exclusion.
Building on a successful Ph 1 study demonstrating a favorable safety profile and highly encouraging efficacy signals across solid tumor types, Cytovation is advancing into Ph 2. Initial focus will be on Adrenocortical Carcinoma, a rare b-catenin-driven cancer, which can allow a fast route-to-market, while opening the door to broader b-catenin-driven indications, like HCC and CRC.